{"id":10617,"date":"2024-01-16T14:09:48","date_gmt":"2024-01-16T07:09:48","guid":{"rendered":"https:\/\/www.research.chula.ac.th\/center-of-excellence-in-bone-disorders-and-enzyme-reaction-mechanisms\/"},"modified":"2024-06-14T15:47:55","modified_gmt":"2024-06-14T08:47:55","slug":"ce-bone-disorders-and-enzyme-reaction-mechanisms","status":"publish","type":"page","link":"https:\/\/www.research.chula.ac.th\/en\/ce-bone-disorders-and-enzyme-reaction-mechanisms\/","title":{"rendered":"Center of Excellence in bone disorders and enzyme reaction mechanisms"},"content":{"rendered":"\t\t
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The ultimate goal of our Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism is to foster interdisciplinary and collaborative works that lead to facilitate the understanding of skeletal biology, the discovery of disease mechanism and the effect of cannabinoid compounds on anti-inflammatory effect in osteoblasts. Our group will provide the expertise, state-of-the-art resources, and the training necessary to promote cutting edge skeletal and enzyme mechanistic study research<\/p>

Understanding skeleton and cellular mechanisms underlying related disease is of the utmost importance for diagnosis and therapeutic intervention. Our group is particularly interested in developing a strong skeletal disease and enzyme reaction mechanism program to complement existing expertise at the Faculty of Dentistry. We aim to establish an excellent Center of Excellence and bring together expertise from immunologist, biochemists and physiologist to further develop our research in the future. The immunological aspects of musculoskeletal diseases eg. osteoarthritis, will be explored. Understanding the immune-mediated mechanisms, inflammation and how the immune system plays a role in the pathogenesis of osteoarthritis may lead to applications in (immuno)therapy for this disease. These studies are based on human models through collaboration with clinicians in the orthopedics field. Our work also expands to using biologics in treating osteoarthritis patients and understanding the biochemistry behind it.<\/p>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Periodontitis is a major problem in periodontal disease involved in inflammation. The inflammation process in response of microbes leads to alveolar bone loss. The disease is a major problem in oral health including systemic disorder. Inhibition of inflammatory response prevents bone loss. THCA cannabinoid compound is potentially inhibitor of inflammatory process. However, to obtain high yield of THCA, the recombinant enzyme THCA synthase for biosynthesis of THCA from lower cost starting compound of cannabigerlolic acid using yeast expression system will be developed. This compound will be applied for the drug for therapeutic use in periodontal disease or use for oral rehabilitation to preserve bone after resolution of microbes.<\/p>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Target in 3 Years<\/h3>\t\t<\/div>\n\t\t\n\t\t\t\t
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Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism is to foster interdisciplinary and collaborative works.<\/p>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Research Highlights<\/h3>\t\t<\/div>\n\t\t\n\t\t\t\t
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  1. Characterization of skeletal phenotype in genetically modified mice and pathophysiology of osteoporosis and periodontitis and treatment.<\/li>
  2. To study the immune responses in diseases related to bone and joints eg. osteoarthritis and the immune role of chondrocytes, which are target cells for destruction in certain joint diseases<\/li>
  3. To study the method for optimization of condition for high yield of expression of Tetrahydrocannabinolic acid (THCA) synthase in yeast system and inhibition of THCA on anti-inflammatory effect in osteoblasts<\/li><\/ol>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    • Harvard School of Dental Medicine<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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      • Cornell University<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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        • Mahidol University<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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          \n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFaculty of Dentistry Chulalongkorn University 34 Henry Dunant Road, Wang Mai Subdistrict, Pathumwan District, Bangkok 10330\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

          The ultimate goal of our Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism is to foster interdisciplinary and collaborative works that lead to facilitate the understanding of skeletal biology, the discovery of disease mechanism and the effect of cannabinoid compounds on anti-inflammatory effect in osteoblasts. Our group will provide the expertise, state-of-the-art resources, and the training necessary to promote cutting edge skeletal and enzyme mechanistic study research Understanding skeleton and cellular mechanisms underlying related disease is of the utmost importance for diagnosis and therapeutic intervention. Our group is particularly interested in developing a strong skeletal disease and enzyme reaction mechanism program to complement existing expertise at the Faculty of Dentistry. We aim to establish an excellent Center of Excellence and bring together expertise from immunologist, biochemists and physiologist to further develop our research in the future. The immunological aspects of musculoskeletal diseases eg. osteoarthritis, will be explored. Understanding the immune-mediated mechanisms, inflammation and how the immune system plays a role in the pathogenesis of osteoarthritis may lead to applications in (immuno)therapy for this disease. These studies are based on human models through collaboration with clinicians in the orthopedics field. Our work also expands to using biologics in treating osteoarthritis patients and understanding the biochemistry behind it. Research & Innovation Focus \u200b Health and Well-Being + Health NetZero + Health Sustainable Society + Health Strategic Objectives Periodontitis is a major problem in periodontal disease involved in inflammation. The inflammation process in response of microbes leads to alveolar bone loss. The disease is a major problem in oral health including systemic disorder. Inhibition of inflammatory response prevents bone loss. THCA cannabinoid compound is potentially inhibitor of inflammatory process. However, to obtain high yield of THCA, the recombinant enzyme THCA synthase for biosynthesis of THCA from lower cost starting compound of cannabigerlolic acid using yeast expression system will be developed. This compound will be applied for the drug for therapeutic use in periodontal disease or use for oral rehabilitation to preserve bone after resolution of microbes. Target in 3 Years Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism is to foster interdisciplinary and collaborative works. Research Highlights Characterization of skeletal phenotype in genetically modified mice and pathophysiology of osteoporosis and periodontitis and treatment. To study the immune responses in diseases related to bone and joints eg. osteoarthritis and the immune role of chondrocytes, which are target cells for destruction in certain joint diseases To study the method for optimization of condition for high yield of expression of Tetrahydrocannabinolic acid (THCA) synthase in yeast system and inhibition of THCA on anti-inflammatory effect in osteoblasts Networks and Partnerships Harvard School of Dental Medicine Cornell University Mahidol University Contact Associate Professor Dr. Suthada Lotinan Director of Research projects Faculty of Medicine Affiliation Faculty of Dentistry Chulalongkorn University 34 Henry Dunant Road, Wang Mai Subdistrict, Pathumwan District, Bangkok 10330<\/p>\n","protected":false},"author":1,"featured_media":10603,"parent":0,"menu_order":121,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_eb_attr":"","footnotes":""},"class_list":["post-10617","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nCenter of Excellence in bone disorders and enzyme reaction mechanisms - Research Chula<\/title>\n<meta name=\"description\" content=\"The ultimate goal of our Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism is to foster interdisciplinary and collaborative works that lead to facilitate the understanding of skeletal biology, the discovery of disease mechanism and the effect of cannabinoid compounds on anti-inflammatory effect in osteoblasts. 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