{"id":11152,"date":"2024-05-31T14:45:49","date_gmt":"2024-05-31T07:45:49","guid":{"rendered":"https:\/\/www.research.chula.ac.th\/center-of-expertise-in-clinical-pharmacokinetics-and-pharmacogenomics\/"},"modified":"2024-06-15T15:41:53","modified_gmt":"2024-06-15T08:41:53","slug":"ce-clinical-pharmacokinetics-and-pharmacogenomics","status":"publish","type":"page","link":"https:\/\/www.research.chula.ac.th\/en\/ce-clinical-pharmacokinetics-and-pharmacogenomics\/","title":{"rendered":"Center of Excellence in Clinical Pharmacokinetics and Pharmacogenomics"},"content":{"rendered":"\t\t
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Research in the area of pharmacokinetics, pharmacodynamics and pharmacogenetics to increase efficacy and safety in the use of drugs in patients<\/p>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Research & Innovation Focus \u200b<\/h2>\t\t<\/div>\n\t\t\n\t\t\t\t
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Target in 3 Years<\/h3>\t\t<\/div>\n\t\t\n\t\t\t\t
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Research in the area of pharmacokinetics, pharmacodynamics and pharmacogenetics to increase efficacy and safety in the use of antituberculosis drugs, immunosuppressive drugs and antiplatelet drugs in Thai patients<\/p>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Research Highlights<\/h3>\t\t<\/div>\n\t\t\n\t\t\t\t
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  1. HLA-B*46:01:01:01 and HLA-DRB1*09:01:02:01 are associated with anti-rHuEPO-induced pure red cell aplasia. Suttichet TB, Chamnanphon M, Pongpanich M, Chokyakorn S, Kupatawintu P, Srichomthong C, Chetruengchai W, Chuntakaruk H, Rungrotmongkol T, Chariyavilaskul P, Shotelersuk V, Praditpornsilpa K. Sci Rep. 2023 Dec 20;13(1):22759. doi: 10.1038\/s41598-023-50211-3.<\/li>
  2. Pharmacokinetics of isoniazid and rifapentine in young pediatric patients with latent tuberculosis infection. Phaisal W, Jantarabenjakul W, Wacharachaisurapol N, Tawan M, Puthanakit T, Wittayalertpanya S, Chariyavilaskul P. Int J Infect Dis. 2022 Sep;122:725-732. doi: 10.1016\/j.ijid.2022.07.040. Epub 2022 Jul 19.<\/li>
  3. A first update on mapping the human genetic architecture of COVID-19. COVID-19 Host Genetics Initiative. Nature. 2022 Aug;608(7921):E1-E10. doi: 10.1038\/s41586-022-04826-7. Epub 2022 Aug 3.<\/li>
  4. Whole-genome sequencing reveals host factors underlying critical COVID-19. Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD. , Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC investigators; 23andMe investigators; COVID-19 Human Genetics Initiative; Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Nature. 2022 Jul;607(7917):97-103. doi: 10.1038\/s41586-022-04576-6. Epub 2022 Mar 7.<\/li>
  5. Genotypic and phenotypic landscapes of 51 pharmacogenes derived from whole-genome sequencing in a Thai population. Wankaew N, Chariyavilaskul P, Chamnanphon M, Assawapitaksakul A, Chetruengchai W, Pongpanich M, Shotelersuk V. PLoS One. 2022 Feb 17;17(2):e0263621. doi: 10.1371\/journal.pone.0263621. eCollection 2022.<\/li>
  6. Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach.<\/li>
  7. Rattanacheeworn P, Kerr SJ, Kittanamongkolchai W, Townamchai N, Udomkarnjananun S, Praditpornsilpa K, Thanusuwannasak T, Udomnilobol U, Jianmongkol S, Ongpipattanakul B, Prueksaritanont T, Avihingsanon Y, Chariyavilaskul P. Front Pharmacol. 2021 Sep 17;12:726669. doi: 10.3389\/fphar.2021.726669. eCollection 2021.<\/li><\/ol>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      • Faculty of Science, Chulalongkorn University<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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            \n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDepartment of Pharmacology, Faculty of Medicine, Chulalongkorn University, 10th Floor Pattayapat Building, Rama IV road, Pathumwan Bangkok 10330 \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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            \n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTel. (+66) 225 64481\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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            \n\t\t\t\t\t\t\n\t\t\t\t\t\t\tE-mail: pajaree.l@chula.ac.th\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

            Research in the area of pharmacokinetics, pharmacodynamics and pharmacogenetics to increase efficacy and safety in the use of drugs in patients Research & Innovation Focus \u200b Health and Well-Being + Health Health and Well-Being + BCG Health and Well-Being + Industry 4.0 Strategic Objectives Health – Health and Well-being Target in 3 Years Research in the area of pharmacokinetics, pharmacodynamics and pharmacogenetics to increase efficacy and safety in the use of antituberculosis drugs, immunosuppressive drugs and antiplatelet drugs in Thai patients Research Highlights HLA-B*46:01:01:01 and HLA-DRB1*09:01:02:01 are associated with anti-rHuEPO-induced pure red cell aplasia. Suttichet TB, Chamnanphon M, Pongpanich M, Chokyakorn S, Kupatawintu P, Srichomthong C, Chetruengchai W, Chuntakaruk H, Rungrotmongkol T, Chariyavilaskul P, Shotelersuk V, Praditpornsilpa K. Sci Rep. 2023 Dec 20;13(1):22759. doi: 10.1038\/s41598-023-50211-3. Pharmacokinetics of isoniazid and rifapentine in young pediatric patients with latent tuberculosis infection. Phaisal W, Jantarabenjakul W, Wacharachaisurapol N, Tawan M, Puthanakit T, Wittayalertpanya S, Chariyavilaskul P. Int J Infect Dis. 2022 Sep;122:725-732. doi: 10.1016\/j.ijid.2022.07.040. Epub 2022 Jul 19. A first update on mapping the human genetic architecture of COVID-19. COVID-19 Host Genetics Initiative. Nature. 2022 Aug;608(7921):E1-E10. doi: 10.1038\/s41586-022-04826-7. Epub 2022 Aug 3. Whole-genome sequencing reveals host factors underlying critical COVID-19. Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD. , Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC investigators; 23andMe investigators; COVID-19 Human Genetics Initiative; Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Nature. 2022 Jul;607(7917):97-103. doi: 10.1038\/s41586-022-04576-6. Epub 2022 Mar 7. Genotypic and phenotypic landscapes of 51 pharmacogenes derived from whole-genome sequencing in a Thai population. Wankaew N, Chariyavilaskul P, Chamnanphon M, Assawapitaksakul A, Chetruengchai W, Pongpanich M, Shotelersuk V. PLoS One. 2022 Feb 17;17(2):e0263621. doi: 10.1371\/journal.pone.0263621. eCollection 2022. Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach. Rattanacheeworn P, Kerr SJ, Kittanamongkolchai W, Townamchai N, Udomkarnjananun S, Praditpornsilpa K, Thanusuwannasak T, Udomnilobol U, Jianmongkol S, Ongpipattanakul B, Prueksaritanont T, Avihingsanon Y, Chariyavilaskul P. Front Pharmacol. 2021 Sep 17;12:726669. doi: 10.3389\/fphar.2021.726669. eCollection 2021. Networks and Partnerships Faculty of Pharmaceutical Science, Chulalongkorn University Faculty of Science, Chulalongkorn University The HIV Netherland Australia Thailand Research Collaboration (HIVNAT), Thai Red Cross Society King Chulalongkorn Memorial Hospital, Thai Red Cross Society Contact Associate Professor Dr. Pajaree Chariyavilaskul Director of Research projects Faculty of Medicine Affiliation Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, 10th Floor Pattayapat Building, Rama IV road, Pathumwan Bangkok 10330 Tel. (+66) 225 64481 E-mail: pajaree.l@chula.ac.th<\/p>\n","protected":false},"author":4,"featured_media":12123,"parent":0,"menu_order":101,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_eb_attr":"","footnotes":""},"class_list":["post-11152","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nCenter of Excellence in Clinical Pharmacokinetics and Pharmacogenomics - Research Chula<\/title>\n<meta name=\"description\" content=\"Conduct research on important issues in pharmacokinetics. 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