The ultimate goal of our Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism is to foster interdisciplinary and collaborative works that lead to facilitate the understanding of skeletal biology, the discovery of disease mechanism and the effect of cannabinoid compounds on anti-inflammatory effect in osteoblasts. Our group will provide the expertise, state-of-the-art resources, and the training necessary to promote cutting edge skeletal and enzyme mechanistic study research

Understanding skeleton and cellular mechanisms underlying related disease is of the utmost importance for diagnosis and therapeutic intervention. Our group is particularly interested in developing a strong skeletal disease and enzyme reaction mechanism program to complement existing expertise at the Faculty of Dentistry. We aim to establish an excellent Center of Excellence and bring together expertise from immunologist, biochemists and physiologist to further develop our research in the future. The immunological aspects of musculoskeletal diseases eg. osteoarthritis, will be explored. Understanding the immune-mediated mechanisms, inflammation and how the immune system plays a role in the pathogenesis of osteoarthritis may lead to applications in (immuno)therapy for this disease. These studies are based on human models through collaboration with clinicians in the orthopedics field. Our work also expands to using biologics in treating osteoarthritis patients and understanding the biochemistry behind it.