Epigenetic changes are the upstream molecular pathogenesis process. Discovery of the changes brings about new diagnosis and treatment technologies. Our highlight topic is the discovery of a new epigenetic mark called HMGB1-produced DNA gaps or youth-DNA-gap. The reduction of youth-DNA-gap is found in the elderly and senescent cells. The reduction of youth-DNA-gap reduces DNA durability and promotes DNA damage. So the reduction is the upstream molecular pathogenesis process of many diseases. Our CE invented a new medicine composed of Box A of HMGB1 expression plasmid (Box A) to build new DNA gaps. Box A improves DNA durability rejuvenates cells and animals, and cures several chronic brain damage and degenerative diseases in animal models. Box A plasmid DNA can rejuvenate DNA as genomic stability molecules so the nickname of Box A is "REDGEMs DNA".
