Center of Excellence in Translational Research in Inflammation and Immunology
June 12, 2024 2024-06-15 17:08Center of Excellence in Translational Research in Inflammation and Immunology
Center of Excellence in Translational Research in Inflammation and Immunology, The translation of the basic research into clinical practice; bench to bedside translation.
Research & Innovation Focus
Health and Well-Being + Health
Health and Well-Being + BCG
Health and Well-Being + Industry 4.0
Strategic Objectives
- Translation of basic knowledge in the control of inflammation and immune responses into the clinical situation (clinical practice or health advice)
- Discovery of the new knowledge for the control of inflammation and immune responses using translational research
Target in 3 Years
- The innovation
- Probiotics-derived from Thai population (Lacticaseibacillus rhamnosus L34) is developing with Greater Pharma company Thailand and Nephrology unit, Faculty of Medicine, Chulalongorn University to reduce gut-derived uremic toxin.
- The assay for Neutrophil extracellular traps (NETs) measuring CIT-H3 with a collaboration with National Science and Technology Development Agency : NSTDA.
- The plasma flux therapy – an initial machine is successfully built but the indication for using this machine needs more study.
- High rank scientific research and network collaboration
- Enhanced career development and increased funding from out-sources. The increased opportunity of the short-term visit for student will be beneficial for Thai Scientific community .
Research Highlights
- Amornphimoltham P, Yuen PST, Star RA, Leelahavanichkul A. Gut Leakage of Fungal-Derived Inflammatory Mediators: Part of a Gut-Liver-Kidney Axis in Bacterial Sepsis. Dig Dis Sci. 2019 Sep;64(9):2416-2428. (impacts of leaky gut and fungi in the gut contents).
- Chancharoenthana W, Kamolratanakul S, Schultz MJ, Leelahavanichkul A. The leaky gut and the gut microbiome in sepsis - targets in research and treatment. Clin Sci (Lond). 2023 Apr 26;137(8):645-662. (expertise in microbiome analysis and probiotics)
- Charoensappakit A, Sae-Khow K, Rattanaliam P, Vutthikraivit N, Pecheenbuvan M, Udomkarnjananun S, Leelahavanichkul A. Cell-free DNA as diagnostic and prognostic biomarkers for adult sepsis: a systematic review and meta-analysis. Sci Rep. 2023 Nov 10;13(1):19624. (expertise in sepsis)
Networks and Partnerships
- National Science and Technology Development Agency (NSTDA)
- Faculty of Tropical Medicine Mahidol University
- Department of Pharmacology at University of California San Diego School of Medicine; US.
- The University of Queensland; Australia.
- National Institute of Advanced Industrial Science and Technology (AIST); Japan.
- Functional Cellular Networks Section
- National Institute of Allergy and Infectious Diseases National Institutes of Health; US.
